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Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway

15 Jul 2024

Abstract excerpt

Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. Using primary human airway cultures, which recapitulate the diverse epithelial cell landscape of the human airways, we investigated the impact of cell type...

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PMID: 39008691
DOI: 10.1073/pnas.2320303121

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