Article
Can incorporating genotyping data into efficacy estimators improve efficiency of early phase malaria vaccine trials?
Malaria journal - 19 Dec 2023
Potter Gail E, Callier Viviane, Shrestha Biraj, Joshi Sudhaunshu, Dwivedi Ankit, Silva Joana C, Laurens Matthew B, Follmann Dean A, Deye Gregory A
Abstract excerpt
BACKGROUND: Early phase malaria vaccine field trials typically measure malaria infection by PCR or thick blood smear microscopy performed on serially sampled blood. Vaccine efficacy (VE) is the proportion reduction in an endpoint due to vaccination and is often calculated as VEHR = 1-hazard ratio or VERR = 1-risk ratio. Genotyping information can distinguish different clones and distinguish multiple infections...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.