Article

SARS-CoV-2 and the CGG-CGG Furin Site Genetic Fingerprint: Five Years Later

2025-03-06

Abstract excerpt

The key evolutionary step leading to the pandemic virus was the acquisition of the furin cleavage motif at the S protein S1/S2 junction. This insertion led to a gain of function for SARS-CoV-2, in which the virus's S protein became a substrate protein for human furin. The corresponding 12 nucleotide fragment inserted into the S gene in a SARS-CoV-2 precursor included the CGG-CGG genetic fingerprint coding the furi...

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Literature Corpus work: 0aeffbcd-0250-5e7b-9175-1ce28cd8eeff
DOI: 10.20944/preprints202503.0413.v1

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