Article

A glycoRNA switch for malignancy: SNORA73B activates TIAR-dependent oncogenic signaling in lung adenocarcinoma

2026-06-23

Abstract excerpt

Although glycosylated small non-coding RNAs are emerging players in cancer, their functions in lung adenocarcinoma (LUAD) are largely unknown. We identify SNORA73B as a glycosylated small nucleolar RNA (glycol-snoRNA) that carries sialic acid-capped O-glycans in both normal lung epithelial and LUAD cells. SNORA73B is markedly elevated in LUAD, and its plasma levels distinguish early-stage LUAD from healthy control...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0abfb7a8-b571-5570-ab1b-ee7b1ff3c80b
DOI: 10.64898/2026.06.21.733650

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A glycoRNA switch for malignancy: SNORA73B activates TIAR-dependent oncogenic signaling in lung adenocarcinomaDOI 10.64898/2026.06.21.733650Read

Small Nucleolar RNAs as Emerging Players in Cancer Biology and Precision MedicineSemantic proximity Read

The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung AdenocarcinomaSemantic proximity Read

Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas.Semantic proximity Read

snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and ManagementSemantic proximity Read

B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinomaSemantic proximity Read

lncRNA SNHG14 promotes oncogenesis and immune evasion in diffuse large-B-cell lymphoma by sequestering miR-152-3pSemantic proximity Read

GNG7 as a tumor-suppressor gene in lung adenocarcinoma: implications for prognosis and immune-based therapiesSemantic proximity Read

YTHDF1 Facilitates Lung Adenocarcinoma Progression via Promotion of EEF1G Translation in a m6A-Dependent MannerSemantic proximity Read

A cancer-associated RNA polymerase III identity drives robust transcription and expression of SNAR-A noncoding RNASemantic proximity Read

HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemiaSemantic proximity Read

Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyondSemantic proximity Read

The immunomodulation effects of small nuclear ribonucleoprotein polypeptide G (SNRPG) in human brain tumorsSemantic proximity Read