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Two isoforms of pyruvate kinase enzymes in Pseudomonas aeruginosa with distinct functional and structural properties

2019-01-01

Abstract excerpt

In most organisms, phosphofructokinase (PFK) and pyruvate kinase (PK) are the key glycolytic regulatory enzymes. However, the opportunistic human pathogen, Pseudomonas aeruginosa, relies entirely on the Entner-Doudoroff pathway for glycolysis, and consequently, does not encode a PFK homologue. It does encode two PK isozymes though, denoted PykA and PykF. This arrangement is uncommon in bacteria, although when it d...

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Literature Corpus work
0aa2f2ee-ecc8-58bc-90ab-9605e5c95b1f
DOI
10.17863/cam.45135
Open publication

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Two isoforms of pyruvate kinase enzymes in Pseudomonas aeruginosa with distinct functional and structural propertiesDOI 10.17863/cam.45135
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