Article
Transcriptome analysis of a Pseudomonas aeruginosasn-glycerol-3-phosphate dehydrogenase mutant reveals a disruption in bioenergetics.
Microbiology (Reading, England) - 1 Apr 2018
Shuman Jon, Giles Tyler Xavier, Carroll Leslie, Tabata Kenji, Powers Austin, Suh Sang-Jin, Silo-Suh Laura
Abstract excerpt
Pseudomonas aeruginosa causes acute and chronic human infections and is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. We previously determined that the sn-glycerol-3-phosphate dehydrogenase encoded by glpD plays a larger role in P. aeruginosa physiology beyond its role in glycerol metabolism. To better understand the effect of a glpD mutation on P. aeruginosa physiology we compared...
Topics
- Bacterial Proteins
- Energy Metabolism
- Gene Deletion
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Glycerolphosphate Dehydrogenase
- Metabolic Networks and Pathways
- Phenotype
- Pseudomonas aeruginosa