Article
Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000
Rashid M H, Rumbaugh K, Passador L, Davies D G, Hamood A N, Iglewski B H, Kornberg A
Abstract excerpt
The human opportunistic pathogen Pseudomonas aeruginosa causes a variety of infections in immunocompromised hosts and in individuals with cystic fibrosis. A knockout mutation in the polyphosphate kinase (ppk) gene, encoding PPK responsible for the synthesis of inorganic polyphosphate from ATP, renders P. aeruginosa cells unable to form a thick and differentiated biofilm. The mutant is aberrant in quorum sensing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.