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Article

Expression of the retina-specific flippase, ABCA4, in epidermal keratinocytes

2016-02-18

Abstract excerpt

ATP-binding cassette, sub-family A, member 4 (ABCA4) is a photoreceptor transmembrane protein that is responsible for flipping N-retinylidene-phosphatidylethanolamine, a key intermediate in the visual cycle, from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disks. Mutations in ABCA4 cause a build-up of toxic retinoids resulting in a variety of retinal degenerative phenotypes, including Star...

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Literature Corpus work
0a6ef6c1-1b09-54d5-8392-e310cbe98a4e
DOI
10.12688/f1000research.8089.1
Open publication

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Expression of the retina-specific flippase, ABCA4, in epidermal keratinocytesDOI 10.12688/f1000research.8089.1
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