Article

Synergistic effect of perampanel with temozolomide on glioblastoma cells in vivo

2025-03-01

Abstract excerpt

The anti-epileptic drug perampanel, an α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor antagonist, exhibits anti-tumor effects against glioblastoma cells in vitro. This study examined the anti-tumor effects of combination therapy with temozolomide and perampanel on glioblastoma cells both in vitro and in vivo to assess the potential for clinical application. The commercially available glioblastoma cell...

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Literature Corpus work: 09ee07c4-9ebf-51a5-87b2-dea367c5b3af
DOI: 10.1016/j.heliyon.2025.e43167

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