Article
APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells.
International journal of oncology - 1 Mar 2021
De La Rosa Javier, Urdiciain Alejandro, Zelaya María V, Zazpe Idoya, Meléndez Bárbara, Rey Juan A, Idoate Miguel A, Castresana Javier S
Abstract excerpt
Glioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy and radiotherapy. Surgery, radiotherapy and chemotherapy with temozolomide are the only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑Nep; an EZH2 inhibitor) and panobinostat (a histone deacetylase inhibitor) are being tested in vitro, together with...
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