Article

WZ35 Induces Metabolic Reprogramming of Hepatoma Cells Through ROS-Mediated Inhibition of YAP-GLUT1 Axis

2021-09-21

Abstract excerpt

<title>Abstract</title> <p><bold>Background: The significant </bold>changes in a series of biochemical activities during the process of tumorigenesis and development, including those in glucose, lipid, and amino acid metabolism can contribute to the ability of the cancer cells to proliferate indefinitely. WZ35 is a new small molecule YAP inhibitor, which can mediate YAP activity to inhibit the growth of gastric c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09ea2a79-3257-594e-915b-a3f79881a45a
DOI: 10.21203/rs.3.rs-898527/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WZ35 Induces Metabolic Reprogramming of Hepatoma Cells Through ROS-Mediated Inhibition of YAP-GLUT1 AxisDOI 10.21203/rs.3.rs-898527/v1Read

Reprogramming of glucose metabolism: The hallmark of malignant transformation and target for advanced diagnostics and treatmentsSemantic proximity Read

METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progressionSemantic proximity Read

Identification of critical genes and biological signaling for metformin treated liver cancerSemantic proximity Read

A New Frontier in Studying Dietary Phytochemicals in Cancer and in Health: Metabolic and Epigenetic ReprogrammingSemantic proximity Read

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose MetabolismSemantic proximity Read

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axisSemantic proximity Read

Loss of MiR-192-5p Initiates a Hyperglycolysis and Stemness Positive Feedback in Hepatocellular Carcinoma.Semantic proximity Read

Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodiesSemantic proximity Read

The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and ChemoresistanceSemantic proximity Read

Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cellsSemantic proximity Read

FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1Semantic proximity Read

Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate IsomeraseSemantic proximity Read