Article

Functional Activity of TDP 43: A Direct Biomarker for ALS

2026-05-04

Abstract excerpt

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synthetic UU-rich RNA probes. We analyzed 1,080 serum samples from controls, sporadic ALS, and genetic subgroups (C9orf72, SOD1) across multip...

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Literature Corpus work: 093e1c7f-8d8c-56b4-962a-80c94f9cb357
DOI: 10.64898/2026.05.04.26352054

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