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Article

Impaired anti-leukemic immune response in PKCtheta-deficient mice.

Molecular immunology - 1 Jul 2008

Garaude Johan, Kaminski Sandra, Charni Seyma, Aguilò Juan Ignacio, Jacquet Chantal, Plays Marc, Hernandez Javier, Rodriguez Fernando, Hipskind Robert A, Anel Alberto, Villalba Martin

Abstract excerpt

The cancer immunosurveillance hypothesis has found strong experimental support in recent years. It is believed that cytotoxic lymphocytes are important effectors in this process. PKCtheta plays an essential role in proliferation, activation and survival of these cells, but also proliferation and survival of leukemic T cells. In light of this, we tested the role of PKCtheta in T cell leukemia progression by...

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Identifiers

PMID: 18462800
DOI: 10.1016/j.molimm.2008.03.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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