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Toll like Receptor signalling by <i>Prevotella histicola</i> activates alternative NF-κB signalling in Cystic Fibrosis bronchial epithelial cells compared to <i>P.aeruginosa</i>

2020-06-24

Abstract excerpt

Cystic Fibrosis (CF), caused by mutations affecting the CFTR gene, is characterised by viscid secretions in multiple organ systems. CF airways contain thick mucus, creating a gradient of hypoxia, which promotes the establishment of polymicrobial infection. Such inflammation predisposes to further infection, a self-perpetuating cycle in mediated by NF-κB. Anaerobic Gram-negative Prevotella spp. are found in sputu...

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Literature Corpus work
5666176b-1bfb-5dd8-b6bd-b37ac3b269fa
DOI
10.1101/2020.06.24.168682
Open publication

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Toll like Receptor signalling by <i>Prevotella histicola</i> activates alternative NF-κB signalling in Cystic Fibrosis bronchial epithelial cells compared to <i>P.aeruginosa</i>DOI 10.1101/2020.06.24.168682
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