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High-depth whole genome sequencing of blood culture plates reveals evolutionary dynamics in cases of persistent bacteremia due to methicillin-resistant <i>Staphylococcus aureus</i>

2026-04-27

Abstract excerpt

Within a single bacterial strain, DNA sequence variation is expected between individual clones. Whole genome sequencing (WGS) can be applied to clinical cultures to detect this polyclonal variation, enabling tracking of within-host evolution and transmission. Culture isolates from infected patients are often sequenced as individual colonies (c-seq). To increase the sensitivity of variant detection, cultures can al...

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Literature Corpus work
090c46c5-2b71-5fb6-9a0e-5e7421df18f5
DOI
10.64898/2026.04.25.720776
Open publication

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High-depth whole genome sequencing of blood culture plates reveals evolutionary dynamics in cases of persistent bacteremia due to methicillin-resistant <i>Staphylococcus aureus</i>DOI 10.64898/2026.04.25.720776
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