Whole-genome sequencing of Staphylococcus aureus isolates after a decade-long decline in MRSA prevalence at a university referral hospital in Guadalajara, Mexico: clonal concentration in MRSA and greater genetic diversity in MSSA.

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA) prevalence has declined in many settings, but genomic features of residual MRSA populations remain incompletely defined. We performed whole-genome sequencing (WGS) of 26 S. aureus clinical isolates (13 MRSA and 13 methicillin-susceptible S. aureus [MSSA]) collected by stratified random sampling during 2024-2025. Analyses included de novo assembly, species...

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