Article
Whole-genome sequencing for high-resolution investigation of methicillin-resistant Staphylococcus aureus epidemiology and genome plasticity.
Journal of clinical microbiology - 1 Aug 2014
SenGupta Dhruba J, Cummings Lisa A, Hoogestraat Daniel R, Butler-Wu Susan M, Shendure Jay, Cookson Brad T, Salipante Stephen J
Abstract excerpt
Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a major challenge in health care, yet the limited heterogeneity within this group hinders molecular investigations of related outbreaks. Pulsed-field gel electrophoresis (PFGE) has been the gold standard approach but is impractical for many clinical laboratories and is often replaced with PCR-based methods. Regardless, both approaches can prove...
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