Article

Utilization of a cell-penetrating peptide-adaptor for delivery of human papillomavirus protein E2 into cervical cancer cells to arrest cell growth and promote cell death

2022-11-18

Abstract excerpt

<h4>Background: </h4> Human papillomavirus (HPV) is the causative agent of nearly all forms of cervical cancer, which can arise upon viral integration into the host genome and concurrent loss of viral regulatory gene E2. Gene-based delivery approaches show that E2 reintroduction reduces proliferative capacity and promotes apoptosis in vitro. This work explored if our calcium-dependent protein-based delivery system...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 090bb9e6-cfb6-5dae-bca4-578474e9cc3f
DOI: 10.22541/au.166879024.43695518/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Utilization of a cell-penetrating peptide-adaptor for delivery of human papillomavirus protein E2 into cervical cancer cells to arrest cell growth and promote cell deathDOI 10.22541/au.166879024.43695518/v1Read

Utilization of a cell-penetrating peptide-adaptor for delivery of HPV protein E2 into cervical cancer cells to arrest cell growth and promote cell deathSemantic proximity Read

The role of HPV E7 in maintenance of cell transformationSemantic proximity Read

<i>In vitro</i> and <i>in vivo</i> evidences propound therapeutic potential of Lipocalin 2 in cervical carcinomaSemantic proximity Read

Characterization of two distinct immortalized endothelial cell lines, EA.hy926 and HMEC- 1, for in vitro studies: exploring the impact of calcium electroporation, Ca2+ signaling and transcriptomic profilesSemantic proximity Read

Inhibition of ADAM17 increases the cytotoxic effect of cisplatin in cervical spheroids and organoidsSemantic proximity Read

Leading Neuroblastoma Cells To Die by Multiple Premeditated Attacks from a Multifunctionalized NanoconstructSemantic proximity Read

An RNA Aptamer Provides a Novel Approach for the Induction of Apoptosis by Targeting the HPV16 E7 OncoproteinSemantic proximity Read

WAVE1 and WAVE2 facilitate human papillomavirus-driven actin polymerization during cellular entrySemantic proximity Read

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule InhibitorsSemantic proximity Read

Nanoprotrusion enlargement conducts cytocapsular tube elongation along the path of least resistance for metastasis initiationSemantic proximity Read

Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis.Semantic proximity Read

Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cellsSemantic proximity Read