Article
Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis.
The Journal of biological chemistry - 28 Oct 2005
Blachon Stéphanie, Bellanger Sophie, Demeret Caroline, Thierry Françoise
Abstract excerpt
Human Papillomavirus (HPV) E2 proteins are the major viral regulators of transcription and replication during the viral life cycle. In addition to these conserved functions, we show that E2 proteins from high risk HPV types 16 and 18, which are associated with cervical cancer, can induce apoptosis. In contrast, E2 proteins from low risk HPV types 6 and 11, which are associated with benign lesions, do not cause...
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