Article
Disease‑Modifying Trials in Parkinson’s Disease: Challenges, Lessons, and Future Directions
2025-12-12
Abstract excerpt
Parkinson’s disease (PD) is a progressive neurodegenerative disorder lacking approved therapies that slow or halt its underlying pathology. Despite decades of research, disease-modifying trials have faced persistent challenges, including patient heterogeneity, insensitive endpoints, and confounding symptomatic effects. Recent advances in biomarker science and adaptive trial frameworks offer strategies to overcome...
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Identifiers and source
- Literature Corpus work
- 08e17091-8930-5288-9e83-1f0656469706
- DOI
- 10.20944/preprints202512.1091.v1