Article
Disease‑Modifying Therapies for Parkinson’s Disease: Biological Mechanisms, Pharmacological Strategies, and Clinical Pipeline
2025-12-25
Abstract excerpt
Parkinson’s disease (PD) is a biologically heterogeneous neurodegenerative disorder characterized by progressive motor and non-motor symptoms. Despite decades of research, no pharmacologic intervention has conclusively demonstrated disease-modifying efficacy in late-phase randomized controlled trials. Current strategies primarily target pathogenic mechanisms such as α-synuclein aggregation, mitochondrial dysfuncti...
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Identifiers and source
- Literature Corpus work
- a2e88dcf-0a66-59cb-98cc-774a95cad666
- DOI
- 10.20944/preprints202512.2271.v1