Article

Haptoglobin attenuates cerebrospinal fluid hemoglobin-induced neurological deterioration in sheep

2023-12-21

Abstract excerpt

<title>Abstract</title> <p>Background Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI coincides with cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association and convincing pathophysiological concepts suggest that CSF-H...

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Literature Corpus work: 08ae83fb-4a29-5543-92c7-896bf3b5d90e
DOI: 10.21203/rs.3.rs-3737693/v2

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