Article
Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015
Leclerc Jenna L, Blackburn Spiros, Neal Dan, Mendez Nicholas V, Wharton Jeffrey A, Waters Michael F, Doré Sylvain
Abstract excerpt
Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Free hemoglobin (Hb) within the subarachnoid space has been implicated in the pathogenesis of CV. Haptoglobin (Hp) binds free pro-oxidant Hb, thereby modulating its harmful effects. Humans can be of three Hp phenotypes: Hp1-1, Hp2-1, or Hp2-2. In...
Topics
- Adult
- Aged
- Cerebral Angiography
- Disease-Free Survival
- Female
- Genotype
- Haptoglobins
- Humans
- Male
- Middle Aged
- Risk Factors
- Subarachnoid Hemorrhage
- Survival Rate