PGK1 expression differs across breast cancer molecular subtypes and is associated with overall survival in the TCGA BRCA cohort

Abstract excerpt

<title>Abstract</title> <p>Purpose Phosphoglycerate kinase 1 (PGK1) is a glycolytic enzyme implicated in cancer metabolism and breast cancer progression, but reported survival associations may be confounded by molecular subtype and stage. Methods We analyzed official TCGA-BRCA PanCancer Atlas RNA-seq V2 RSEM and clinical files from the cBioPortal DataHub. PGK1 expression was evaluated in 1,082 primary tumors, i...

Topics

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• Biomarkers, Tumor
• Breast Neoplasms
• Computational Biology
• Gene Expression Regulation, Neoplastic
• Microsatellite Instability
• Mutation
• Phosphoglycerate Kinase
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

088faff0-42c8-5024-9652-600dbeb272f1

DOI

10.21203/rs.3.rs-10381279/v1