Article

TMEM180 contributes to colorectal cancer proliferation through intracellular metabolic pathways

2020-07-17

Abstract excerpt

TMEM180, a novel colon cancer–specific membrane protein with a 12-transmembrane topology, is upregulated at low oxygen. Previously, we established a humanized monoclonal antibody against TMEM180 aimed at clinical trials. Prior to such trials, it is necessary to clarify the function of this molecule in cancer. To compare SW480 human colon cancer cells and their TMEM180-knockdown derivatives, we analyzed proliferati...

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Literature Corpus work: 0878a9a8-082e-57d1-b6b6-db365df2f37d
DOI: 10.1101/2020.07.16.207712

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