Article

Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients

2014-09-18

Abstract excerpt

Some somatic single nucleotide variants (SNVs) are thought to be pathogenic, leading to neurological disease. We hypothesized that heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), an autoantigen associated with multiple sclerosis (MS) would contain SNVs. MS patients develop antibodies to hnRNP A1 293-304 , an epitope within the M9 domain (AA 268-305 ) of hnRNP A1. M9 is hnRNP A1’s nucleocytoplasmic trans...

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Literature Corpus work: 08414624-9f0c-5329-9a2c-85ba4c544d8f
DOI: 10.12688/f1000research.4436.2

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