Article

Enzyme Kinetics and Inhibition Parameters of Human Leukocyte Glucosylceramidase

2020-02-24

Abstract excerpt

Glucosylceramidase (GCase) is a lysosomal enzyme that catalyzes the cleavage of β-glucosidic linkage of glucocerebroside (GC) into glucose and ceramide; thereby, plays an essential function in the degradation of complex lipids and the turnover of cellular membranes. The growing list of 460 mutations in the gene coding for it—glucosylceramidase beta acid 1 ( GBA1 )—is reported to abolish its catalytic activity and...

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Literature Corpus work: 079ccf72-3e24-52c9-aff9-575a01b34df2
DOI: 10.1101/2020.02.23.961599

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