Cultured Macrophage Models for the Investigation of Lysosomal Glucocerebrosidase and Gaucher Disease

Abstract excerpt

Macrophages are specialised cells that degrade a range of substrates during their lifetime. In inherited lysosomal storage disorders, particularly the sphingolipidoses, macrophages transform into storage cells and contribute to pathology. An appropriate cultured macrophage model is desired for fundamental research and the assessment of considered therapeutic interventions. We compared commonly used macrophage...

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