Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acid beta-glucosidase: enzymology and molecular biology of Gaucher disease.

Critical reviews in biochemistry and molecular biology - 1 Jan 1990

Grabowski G A, Gatt S, Horowitz M

Abstract excerpt

Human lysosomal beta-glucosidase (D-glucosyl-acylsphingosine glucohydrolase, EC 3.2.1.45) is a membrane-associated enzyme that cleaves the beta-glucosidic linkage of glucosylceramide (glucocerebroside), its natural substrate, as well as synthetic beta-glucosides. Experiments with cultured cells s...

Topics

Amino Acid Sequence
Animals
Base Sequence
Gaucher Disease
Genetic Variation
Glucosylceramides
Glycoproteins
Humans
Molecular Sequence Data
Protein Processing, Post-Translational
Saposins
Sphingolipid Activator Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

beta-Glucosidase

Source

Identifiers

PMID: 2127241
DOI: 10.3109/10409239009090616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2127241-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acid beta-glucosidase: enzymology and molecular biology of Gaucher disease.PMID 2127241Read ↗

Enzyme Kinetics and Inhibition Parameters of Human Leukocyte GlucosylceramidaseSemantic proximity Read ↗

Gaucher disease.Semantic proximity Read ↗

Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease.Semantic proximity Read ↗

The glucocerebrosidase locus in Gaucher's disease: molecular analysis of a lysosomal enzyme.Semantic proximity Read ↗

The metabolism of glucocerebrosides - From 1965 to the present.Semantic proximity Read ↗

Biochemical properties of beta-glucosidase in leukocytes from patients and obligated heterozygotes for Gaucher disease carriers.Semantic proximity Read ↗

Analyses of catalytic activity and inhibitor binding of human acid beta-glucosidase by site-directed mutagenesis. Identification of residues critical to catalysis and evidence for causality of two Ashkenazi Jewish Gaucher disease type 1 mutations.Semantic proximity Read ↗

Human β-glucuronidase: structure, function, and application in enzyme replacement therapy.Semantic proximity Read ↗

Effect of Glu235Ser on enzyme performance and in vitro characterization of human β-glucocerebrosidase in a Pichia pastoris.Semantic proximity Read ↗

Insights into the structural biology of Gaucher disease.Semantic proximity Read ↗

Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythroglucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease.Semantic proximity Read ↗

Clinical phenotype of Gaucher disease in relation to properties of mutant glucocerebrosidase in cultured fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.