Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline DDX41 Variants: Current Understanding and Future Directions.

Current hematologic malignancy reports - 23 Apr 2026

Acosta-Medina Aldo A, Mangaonkar Abhishek A

Abstract excerpt

PURPOSE OF THE REVIEW: To sumarize, provide an overview, and critically assess the currently available literature pertaining to the detection, management, and prognosis of DDX41 germline predisposition syndrome and related myeloid neoplasms. RECENT FINDINGS: DDX41-germline predisposition syndrome is associated with an increased risk of cytopenias, myelodysplastic syndrome, and acute leukemia. Its association with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelodysplastic Syndromes

Share to Prognosis

Source

Identifiers

PMID: 42024186
DOI: 10.1007/s11899-026-00779-0

Genes

DDX41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline DDX41 Variants: Current Understanding and Future Directions.PMID 42024186Read ↗

How to manage patients with germline DDX41 variants: Recommendations from the Nordic working group on germline predisposition for myeloid neoplasmsSemantic proximity Read ↗

Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding.Semantic proximity Read ↗

Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasmsSemantic proximity Read ↗

Germline DDX41 mutations define a significant entity within adult MDS/AML patientsSemantic proximity Read ↗

DDX41-associated susceptibility to myeloid neoplasmsSemantic proximity Read ↗

The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms.Semantic proximity Read ↗

Current Understanding of DDX41 Mutations in Myeloid NeoplasmsSemantic proximity Read ↗

DDX41 mutations in myeloid neoplasms are associated with male gender, TP53 mutations and high‐risk diseaseSemantic proximity Read ↗

The clinical and genomic landscape of patients with DDX41 variants identified during diagnostic sequencingSemantic proximity Read ↗

Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndromeSemantic proximity Read ↗

Myeloid neoplasms with germline DDX41 mutation.Semantic proximity Read ↗

Germline and Somatic Defects in DDX41 and its Impact on Myeloid NeoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.