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Modulation of antioxidant enzyme B166 isoforms 1 and 5 expressions by SREBP1-a links ROS elimination to lipid metabolism in glioblastoma cells

2023-11-03

Abstract excerpt

Antioxidant enzyme B166 (B166) - mediated detoxification of H 2 O 2 into water and oxygen is a pivotal process to sustain a favorable redox homeostasis in mitochondria and suppress cell death. Here, we identify that B166 is highly expressed in GBM tumor tissues and a potential novel biomarker to predict unfavorable prognosis of GBM patients. GBM cells upregulate the expression of B166 via SREBP1-a-mediated transcr...

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Literature Corpus work
0672bfa4-5d80-5d14-b595-182fb69cc069
DOI
10.21203/rs.3.rs-3542956/v1
Open publication

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Modulation of antioxidant enzyme B166 isoforms 1 and 5 expressions by SREBP1-a links ROS elimination to lipid metabolism in glioblastoma cellsDOI 10.21203/rs.3.rs-3542956/v1
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