Article

Acquired Resistance to Colistin via Chromosomal And Plasmid-Mediated Mechanisms in Klebsiella pneumoniae

2019-09-01

Abstract excerpt

Abstract The increasing prevalence of resistance to the last-resort antibiotics carbapenems is leading to increasing difficulties in treating infections caused by multidrug-resistant carbapenem-resistant Gram-negative bacteria such as Klebsiella pneumoniae. The situation has led to the reintroduction of a drug previously discontinued for use in humans - colistin. Colistin is a cationic polypeptide which binds to t...

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Literature Corpus work: 05e20cc6-fb7f-5aa9-9c04-a084e2fe4ff4
DOI: 10.1097/im9.0000000000000002

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