Article
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth.
Nature communications - 14 Feb 2024
Kellaway Sophie G, Potluri Sandeep, Keane Peter, Blair Helen J, Ames Luke, Worker Alice, Chin Paulynn S, Ptasinska Anetta, Derevyanko Polina K, Adamo Assunta, Coleman Daniel J L, Khan Naeem, Assi Salam A, Krippner-Heidenreich Anja, Raghavan Manoj, Cockerill Peter N, Heidenreich Olaf, Bonifer Constanze
Abstract excerpt
Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating blast cell population with fatal consequences for the patient if not treated. The most common treatment option is still chemotherapy which targets such cells. However,...
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