Article

Enhancer RNA-based modeling of adverse events and objective responses of immunotherapy

2021-12-17

Abstract excerpt

Immune checkpoint inhibitors (ICI) targeting PD-1/PD-L1 or CTLA-4 are emerging and effective immunotherapy strategies. However, ICI treated patients present heterogeneous responses and adverse events, thus demanding effective ways to assess benefit over risk before treatment. Here, by integrating pan-cancer clinical and molecular data, we tried to predict immune-related adverse events (irAEs, risk) and objective r...

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Literature Corpus work: 05d106c2-6481-5242-948a-6613f59b21b8
DOI: 10.1101/2021.12.16.473069

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