Article

Specification of the germline by Nanos-dependent down-regulation of the somatic synMuvB transcription factor LIN-15B

2017-07-14

Abstract excerpt

The Nanos RNA-binding protein has been implicated in the specification of primordial germ cells (PGCs) in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of PGCs lacking the nanos homologues nos-1 and nos-2 i C. elegans . nos-1nos-2 PGCs fail to silence hundreds of genes normally expressed in oocytes and somatic cells, a phenotype reminiscent of PGCs lacki...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05c97d2e-0bb6-5c2b-8f9d-eaa8e3d93288
DOI: 10.1101/163642

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Specification of the germline by Nanos-dependent down-regulation of the somatic synMuvB transcription factor LIN-15BDOI 10.1101/163642Read

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegansSemantic proximity Read

A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans.Semantic proximity Read

Nanos downregulates maternal mRNAs in germline during Drosophila early embryogenesisSemantic proximity Read

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.Semantic proximity Read

LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.Semantic proximity Read

Conserved role of nanos proteins in germ cell development.Semantic proximity Read

MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegansSemantic proximity Read

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read

<i>C. elegans</i> synMuv B proteins regulate spatial and temporal chromatin compaction during developmentSemantic proximity Read

The Role of Nanos in Germ Granules—Putative Posttranscriptional Regulation Hubs in Germ Cell Specification and Development Across SpeciesSemantic proximity Read

Germline development in rat revealed by visualization and deletion of Prdm14Semantic proximity Read

gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Semantic proximity Read