Article

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

2021-05-25

Abstract excerpt

Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease resulting in defective filtration and albuminuria. Lack of endogenous thymosin β4 (TB4), an actin sequestering peptide, exacerbates glomerular injury and disrupts the or...

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Literature Corpus work: 05a7c96a-4132-580a-8a8c-21d0a4a4fa0a
DOI: 10.1101/2021.05.24.445384

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