Article

Lacer: accurate base quality score recalibration for improving variant calling from next-generation sequencing data in any organism

2017-04-25

Abstract excerpt

Next-generation sequencing data is accompanied by quality scores that quantify sequencing error. Inaccuracies in these quality scores propagate through all subsequent analyses; thus base quality score recalibration is a standard step in many next-generation sequencing workflows, resulting in improved variant calls. Current base quality score recalibration algorithms rely on the assumption that sequencing errors ar...

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Literature Corpus work: 059d51d6-5337-5607-9168-6483ea2e0c2d
DOI: 10.1101/130732

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