Article
DNA methylation profiling of meningiomas highlights clinically distinct molecular subgroups.
Journal of neuro-oncology - 1 Jan 2023
Singh Jyotsna, Sharma Ravi, Shukla Nidhi, Narwal Priya, Katiyar Amit, Mahajan Swati, Sahu Saumya, Garg Ajay, Sharma Mehar C, Suri Ashish, Sarkar Chitra, Suri Vaishali
Abstract excerpt
BACKGROUND: Introduction of the classification of brain tumours based on DNA methylation profile has significantly changed the diagnostic approach. Due to the paucity of data on the molecular profiling of meningiomas and their clinical implications, no effective therapies and new treatments have been implemented. METHODS: DNA methylation profiling, copy number analysis, targeted sequencing and H3K27me3 expression...
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