Article

Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy

2024-11-04

Abstract excerpt

<h4>Background</h4> Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease of the central nervous system caused by JC virus (JCV). Survival is dependent on early diagnosis and ability to re-establish anti-viral T cell immunity. Adoptive transfer of polyomavirus-specific T cells has shown promise; however, there are no readily available HLA-matched anti-viral T cells to facilitate rapid tre...

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Literature Corpus work: 04644679-7136-503b-a0ca-c87372b4d506
DOI: 10.1101/2024.11.04.621904

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