Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCA4-mutant human retinal organoids sequencing reveals organoids application in inherited retinal diseases.

Experimental eye research - 1 Dec 2025

Bao Yourong, Soh Sujung, Li Jean, Zuo Zhen, Ferdous Salma, Qian Xinye, Li Jin, Lu Jiaxiong, Cheng Xuesen, Matynia Anna, Li Yumei, Chen Rui

Abstract excerpt

In the studies of Inherited Retinal Diseases (IRDs), the knockout of traditional animal models like mice often fails to accurately replicate human phenotypes due to genetic and anatomical differences. Human retinal organoids (ROs) derived from stem cells have emerged as promising developmental models in retinal studies to delineate cell growth, but their ability to represent the characteristics of late-onset IRDs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to ABCA4 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Organoids

Share to Retina

Share to Retinal Diseases

Share to Stargardt Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 41038369
DOI: 10.1016/j.exer.2025.110677
PMCID: PMC13133920

Genes

ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCA4-mutant human retinal organoids sequencing reveals organoids application in inherited retinal diseases.PMID 41038369Read ↗

Unravelling genotype-phenotype correlations in Stargardt disease using patient-derived retinal organoidsSemantic proximity Read ↗

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease mapSemantic proximity Read ↗

Retinal Organoids: A Human Model System for Development, Diseases, and Therapies.Semantic proximity Read ↗

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitroSemantic proximity Read ↗

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.Semantic proximity Read ↗

Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesisSemantic proximity Read ↗

Single-Cell Transcriptomic Dataset of RPGR-associated Retinitis Pigmentosa Patient-Derived Retinal Organoids.Semantic proximity Read ↗

Loss of ABCA4 from photoreceptor discs triggers changes in glial cell homeostasisSemantic proximity Read ↗

Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin.Semantic proximity Read ↗

Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.Semantic proximity Read ↗

Identification and characterization of human retinal stem cells capable of retinal regenerationSemantic proximity Read ↗

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.