Article

RIPK3-dependent necroptosis is the primary cause of RIPK1-deficient-induced immunodeficiency

2023-02-22

Abstract excerpt

RIPK1 (receptor-interacting serine/threonine kinase 1) plays a pivotal role in developing the immune system—patients with homozygous loss-of-function mutations of RIPK1 present with immunodeficiency and intestinal inflammation. Here, we reported that RIPK1-deficient rats represented defects of human patients and were certified as a suitable disease model. Knocking out Ripk3 rather than Caspase-8 nearly completel...

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Literature Corpus work: 03d27aa1-db2d-54ad-ab0e-bb9c005c98cb
DOI: 10.1101/2023.02.22.526137

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