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Article

Differential Subcellular Localization of the Two Alternatively Spliced Isoforms of the Kv3.1 Potassium Channel Subunit in Brain

1 Jul 2002

Abstract excerpt

Voltage-gated K(+) channels containing pore-forming subunits of the Kv3 subfamily have specific roles in the fast repolarization of action potentials and enable neurons to fire repetitively at high frequencies. Each of the four known Kv3 genes encode multiple products by alternative splicing of 3' ends resulting in the expression of K(+) channel subunits differing only in their C-terminal sequence. The...

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PMID: 12091563
DOI: 10.1152/jn.2002.88.1.394

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