Article

Immunoglobulin genes expressed in lymphoblast cell lines discern and predict lithium response in bipolar disorder patients

2022-08-19

Abstract excerpt

<title>Abstract</title> <p>Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes of mania and depression. More than half of BD patients are non-responsive to lithium, the first-line treatment drug, complicating BD clinical management. Given its unknown etiology, it is pertinent to understand the genetic signatures that lead to variability in lithium treatment. We discovered a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03a945b1-ff40-5543-a55e-002035c7a1ca
DOI: 10.21203/rs.3.rs-1963227/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin genes expressed in lymphoblast cell lines discern and predict lithium response in bipolar disorder patientsDOI 10.21203/rs.3.rs-1963227/v1Read

Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patientsSemantic proximity Read

Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorderSemantic proximity Read

Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines.Semantic proximity Read

Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorderSemantic proximity Read

Predicting lithium treatment response in bipolar patients using gender-specific gene expression biomarkers and machine learningSemantic proximity Read

A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1Semantic proximity Read

Pharmacogenomics of Bipolar DisorderSemantic proximity Read

Convergent analysis of genome‐wide genotyping and transcriptomic data suggests association of zinc finger genes with lithium response in bipolar disorderSemantic proximity Read

Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral LymphocytesSemantic proximity Read

Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorderSemantic proximity Read

Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.Semantic proximity Read

Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysisSemantic proximity Read