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A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1

22 Jul 2020

Abstract excerpt

Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed retrospectively) is associated with distinct blood DNA methylation profiles. Bisulfite-treated total...

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PMID: 32699220
DOI: 10.1038/s41598-020-69073-0

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