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Updates on Diagnosis and Treatment of PIK3CA-Related Overgrowth Spectrum.

Annals of plastic surgery - 1 May 2023

Chen Hongrui, Gao Wei, Liu Hongyuan, Sun Bin, Hua Chen, Lin Xiaoxi

Abstract excerpt

ABSTRACT: Hyperactivation of the PI3K/AKT/mTOR signaling pathway caused by PIK3CA mutations is associated with a category of overgrowth syndromes that are defined as PIK3CA -related overgrowth spectrum (PROS). The clinical features of PROS are highly heterogeneous and usually present as vascular malformations, bone and soft tissue overgrowth, and neurological and visceral abnormalities. Detection of PIK3CA...

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PMID: 36729078
DOI: 10.1097/SAP.0000000000003389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Updates on Diagnosis and Treatment of PIK3CA-Related Overgrowth Spectrum.PMID 36729078Read ↗

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Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.Semantic proximity Read ↗

PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With AlpelisibSemantic proximity Read ↗

[PIK3CA-related overgrowth syndrome (PROS)].Semantic proximity Read ↗

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies.Semantic proximity Read ↗

Phenotypic and molecular characterization of five patients with PIK3CA-related overgrowth spectrum (PROS).Semantic proximity Read ↗

A challenging diagnosis of the PIK3CA-related overgrowth spectrum.Semantic proximity Read ↗

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Alpelisib for treatment of patients with PIK3CA-related overgrowth spectrum (PROS).Semantic proximity Read ↗

Molecular and Functional Characterization of Three Different Postzygotic Mutations in PIK3CA-Related Overgrowth Spectrum (PROS) Patients: Effects on PI3K/AKT/mTOR Signaling and Sensitivity to PIK3 Inhibitors.Semantic proximity Read ↗

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