Article

Radiological Evaluation of the Natural History of PIK3CA-Related Overgrowth Spectrum (PROS)

2026-03-10

Abstract excerpt

PIK3CA -related overgrowth spectrum (PROS) comprises a heterogeneous group of disorders caused by postzygotic activating variants in PIK3CA , leading to mosaic activation of the PI3K pathway. PROS natural history is highly variable across patients and depends on the timing and distribution of the somatic mutation. To better characterize this natural history, we analyzed a cohort of patients with PROS. This multi...

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Literature Corpus work: 7c6435e5-46d6-5b22-907a-0abaa7954089
DOI: 10.64898/2026.03.09.26347786

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