Transmembrane polar relay drives the allosteric regulation for ABCG5/G8 sterol transporter

Abstract excerpt

The heterodimeric ATP-binding cassette (ABC) sterol transporter, ABCG5/G8, is responsible for the biliary and transintestinal secretion of cholesterol and dietary plant sterols. Missense mutations of ABCG5/G8 can cause sitosterolemia, a loss-of-function disorder characterized by plant sterol accumulation and premature atherosclerosis. A new molecular framework was recently established by a crystal structure of hum...

Topics

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• ATP Binding Cassette Transporter, Subfamily G, Member 5
• ATP Binding Cassette Transporter, Subfamily G, Member 8
• Cholesterol Esters
• Intestinal Diseases
• Lipid Metabolism, Inborn Errors
• Phytosterols
• Protein Conformation, alpha-Helical
• Protein Conformation, beta-Strand

Identifiers and source

Literature Corpus work

02ea3f9a-2086-5dd3-b756-277df96637a1

DOI

10.1101/2020.10.06.327825