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Article

Targeted pharmacotherapies for defective ABC transporters.

Biochemical pharmacology - 15 Jul 2017

Vauthier Virginie, Housset Chantal, Falguières Thomas

Abstract excerpt

Human ABC (ATP Binding Cassette) transporters form a superfamily of forty-eight transmembrane proteins, which transport their substrates across biological membranes against important concentration gradients, in an energy-dependent manner. Gene variations in approximately half of these transporters have been identified in subjects with rare and often severe genetic diseases, highlighting the importance of their...

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Identifiers

PMID: 28245962
DOI: 10.1016/j.bcp.2017.02.020

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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