Article

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

2023-08-23

Abstract excerpt

Antigen processing is critical for producing epitope peptides that are presented by HLA molecules for T cell recognition. Therapeutic vaccines aim to harness these epitopes for priming cytotoxic T cell responses against cancer and pathogens, but insufficient processing often reduces vaccine efficacy through limiting the quantity of epitopes released. Here, we set out to improve antigen processing by harnessing pro...

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Literature Corpus work: 02d6fcf5-e578-534a-a4c0-d88ab9161052
DOI: 10.1101/2023.08.22.554289

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