Article

Ultrasound-guided left heart injection: a safer and more efficient strategy for mouse thoracic aortic gene delivery

2025-09-03

Abstract excerpt

<title>Abstract</title> <p>Thoracic aortic disease poses a significant threat due to its high mortality rates and genetic underpinnings. While gene therapy holds promise for cures, the challenge lies in achieving effective and safe gene delivery to the thoracic aorta. Tail vein injection (TI), is hindered by off-target effects and hepatotoxicity, and traditional blinded percutaneous left heart injection (TLI) car...

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Literature Corpus work: 02998718-5dac-5936-93a7-ae5cb80fdc4a
DOI: 10.21203/rs.3.rs-7412569/v1

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